Endocrine Abstracts

The most common reason for the rare condition of hyperinsulinemia-related hypoglycaemia is insulinoma, a tumor of pancreatic islet cells. However, nesidioblastosis characterized by diffuse or focal hyperplasia of the pancreatic islet cells is the most common cause of hyperinsulinemic hypoglycemia in newborns. Nesidioblastosis seen in newborns is now called ‘persistent hyperinsulinemic hypoglycemia of infancy’ (PHHI) while the condition in adults is called ‘nonin...

Dopamine agonists are the treatment of choice for prolactinomas and surgery is warranted only when the response to medical therapy is poor, not tolerated, or in those with compromised vision or with extensive invasion. We describe the two cases of a giant prolactinoma treated with cabergoline alone and next to surgery and gamma-knife.Case 1: A 30-year-old man admitted with headache and visual defect, cranial magnetic resonance imaging (MRI) revealed a in...

Introduction: The involvement of certain organs such as the adrenal gland is rare in non-Hodgkin’s lymphoma (NHL). Although lymphomas can involve virtually all extranodal organs, different organs show different frequency of involvement. Adrenal gland involvement is usually bilateral. We report that a rare case of unilateral adrenal involvement of diffuse large B-cell lymphoma presenting with abdominal pain.Case: A 64-year-old-man presented with abdo...

A 27-year-old woman with had sweating flushing attacks for three years prior to pregnancy, but did not follow with any medical examination. At 12th gestational week, hypertension was detected and alpha-methyldopa was started, no abnormal findings were found in the routine examinations, in the 24-h holter study, blood pressure values (using alpha-methyldopa) were found to be higher than 144/99 (general), 147/101 (awake) and 134/92 mmHg (sleep). 24-hour urinary levels of catecho...

Introduction: Hypervitaminosis D is a rarely reported condition. It may be observed more frequently because of the recent increase in supplement use of vitamin D. Herein, we report a case of vitamin D intoxication which was the first case with this high level of calcium as we searched the literature.Case report: A 57-year old hypertensive woman admitted to our emergency room with symptoms of constipation, loss of appetite and confusion. Blood pressure, h...

Primary Hyperparathyroidism is a common endocrine disorder characterized with high parathyroid hormone (PTH) and calcium (Ca) levels. Although most of the patients are asymptomatic, some patients may be presented with renal, gastrointestinal, musculoskeletal, neurologic or cardiovascular signs associated with hypercalcemia or elevated parathyroid hormone related findings such as bone disease, nephrolithiasis, hypophosphatemia increased production of calcitriol, hypomagnesemia,...

Background: Brown tumor of bone is a non-neoplastic lesion resulting from abnormal bone metabolism in hyperparathyroidism. Brown tumor, as the only and initial symptom of normocalcemic primary hyperparathyroidism is extremely rare.Case presentation: A 69-year-old female patient was admitted to the hospital with a mass in the right thigh. A mass lesion of the right distal femur with bone and soft tissue infiltration was observed in the lower extremity mag...

Background: Obesity and diabetes are major causes of morbidity and mortality that are increasing all over the world. As obesity is a major risk factor for type 2 diabetic patients, weight loss has an important place in the treatment of type 2 diabetic patients. In our study, it’s aimed to evaluate the effects of exenatide and laparoscopic sleeve gastrectomy (LSG) in obese diabetic patients on the clinical and laboratory parameters.Subjects and metho...

Background: Aggressive pituitary adenomas (APAs) take place phenotypically between benign pituitary adenomas and pituitary carcinomas with systemic metastasis. Frequent recurrence and resistance to conventional treatments are characteristic features of APAs in their clinical course. Temozolomide is an alkylating agent that has been used in the treatment of pituitary carcinomas and APAs since 2006. Herein, we report a patient who received temozolomide treatment due to APA.<...

Background: Because of prolong exposure to elevated endogenous growth hormone (GH) and insulin-like growth factor (IGF-1) levels in acromegaly, it is resulted in multipl comorbidities such as somatic growth, hypertension, diabetes and sleep apnea. Systemic complications caused by acromegaly include gastrointestinal (GIS) involvement. In our study it was planned to evaluate the upper GIS findings by using endoscopic and ultrasonographic methods in acromegaly patients.<p cla...